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High levels of ATF6 expression have been reported in RA synovium, and pro-inflammatory cytokines such as IL-1 and TNF can induce ATF6 expression in RA-FLS (69)

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Restoration of butyrate-producing bacteria and butyrate levels by ingesting butyrate-rich foods or dietary fibers that lead to butyrate production might provide new treatment options for T2DM and obesity-related metabolic diseases (5)